Cardiac Inflammation Lingers After Covid-19 Resolves JAMA reports.
A study published in the Journal of the American Medical Association, adds to the list of complications that follow a Covid-19 infection with cardiac inflammation being found endemic in recovered patients regardless of previous disease severity.
A JAMA study of 100 recovered Covid-19 patients revealed abnormal cardiovascular magnetic resonance findings in 78 patients (78%) and ongoing myocardial inflammation in 60 patients (60%), which were independent of preexisting conditions, severity and overall course of the acute illness, and time from the original diagnosis.
The study detected these CMR complications in an interquartile range of 64-92 days after initial Covid-19 diagnosis, which demonstrates that Covid-19 leaves a number of marks still visible long after symptoms have disappeared.
The nature of the complications were varying, it was found that "compared with healthy controls and risk factor–matched controls, patients recently recovered from COVID-19 had lower left ventricular ejection fraction, higher left ventricle volumes, higher left ventricle mass, and raised native T1 and T2." Additionally, myocardial late gadolinium enhancement and pericardial enhancement were found.
Endomyocardial biopsy in patients with severe findings revealed active lymphocytic inflammation with no evidence of any viral genome being present, which provides evidence that dampening autoimmune activity might aid in inducing or accelerating complete recovery.
Specific to physicians or formerly infected individuals, the study authors noted that "native T1 and T2 were the measures with the best discriminatory ability to detect COVID-19–related myocardial pathology."