We received dozens of suggestions from Age Reversal Network members after announcing the new COVID-19 landing page on May 3, 2020.
Copied on this landing page are some of the suggestions/comments we received with a brief reply from us when appropriate.
Please know that this website is not meant to be inclusive of the many experimental treatments being tested in the clinical setting today.
Consider an IL-6 level of ≥ 50 as a tentative indicator for IL-6 antagonist therapy. You have drugs used for treating RA that are IL-6 antagonists. Therefore, in a patient with documented COVID-19 and abnormal inflammation markers, I would not anticipate any problem in suppressing IL-6 levels. We should use these drugs to prevent the emergence of cytokine storm, rather than treat it reactively. Not convinced about using cimetidine as Interferon type 1 inducer. (We will insert your suggestion into the master document on the website consideration be given of an IL-6 blood level over 50 pg/mL (in addition to 80-100 pg/mL found by other researchers) as basis to contemplate IL-6 suppression therapy. There is still concern related to premature shutdown of IL-6, so I hope to hear from some front line intensivists as to what results they observe in patients treated earlier with Actemra and other cytokine antagonists. Here are links to some studies on cimetidine and type 1 interferon-alpha:
You mention IL-6 antagonist tocilizumab (Actemra®) but not sarilumab (Kevzara). There is an FDA approved drug for RA that inhibits IL6, and is a thioredoxin reductase inhibitor, along with inhibiting unfolded protein reaction and ER Stress. That is the agent Auranofin. There is a class of protease inhibitors some of which are already improved and include nitazoxanide (NTZ) aka Alenia, tizoxanide, camostat, nafamostat, disulfiram and vinylsulfone.
There is the very interesting agent that is in clinical trials for prostate cancer (PC) and is an inducer of autophagy called Niclosamide. The Japanese report an RNA-dependent RNA polymerase (RdRp) inhibitor with significant anti-Covid activity: famipiravir (Avigan). One of the protease inhibitors has been shown to be an inhibitor of viral hemagluttinin in the post-translational phase: tizoxanide. (We decided the safety profile on Actemra® may be better than Kevzara®. The study you attached appears to be funded by the makers of Kevzara and it will be interesting to see their results compared to the Actemra studies. We are aware of some of the other suggestions you make and by us posting them, we hope they will be studied in the clinical setting. The purpose of this website is not to be all-inclusive, but to provide insightful data that may not be widely disseminated by the media or other sources.)
UC Davis Launches 2 Clinical Studies to Treat COVID-19
By UC Davis Health Public Aairs on March 31, 2020 in Human & Animal Health
UC Davis Health has two clinical trials underway for hospitalized patients with severe COVID-19, the disease caused by the novel coronavirus, SARS-CoV-2.
The studies are evaluating the safety and eectiveness of two drugs — the investigational antiviral remdesivir, and sarilumab, a drug that blocks the body’s acute inammatory response.
Broad-spectrum antiviral activity of naproxen: from Influenza A to SARS-CoV-2 Coronavirus https://www.biorxiv.org/content/10.1101/2020.04.30.069922v1
Patterns of COVID-19 Mortality and Vitamin D: An Indonesian Study https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3585561
(I will add this to the 75 pages of studies I am accumulating on this topic. Most members maintain optimal vitamin D status and I look forward to clinical trial results that may further enlightened us.
Some time ago my husband and I read every bit of research we could find on successful treatment of covid 19---following which Our Dr. wrote us Rx's for hydroxychloroquine and azithromax--we also bought zinc sulphate. I thought it would be wise to fill the hydroxy rx. before the powers that be found out about it and decided to put draconian restrictions on obtaining it. I was right. The Dr/ we use is a retired pathologist, 76 years old, who is involved in age reversal, having used it on himself for a health problem which is now gone. A few year ago before all of this we had read all the research on fisetin senolytic and rapamycin re: lowering mTOR C1 and removing excessive senescent cells: the goal being so my pancreatic cancer--which was actually cured---could not surface later as some other cancer due to cancer stem cells, mTOR dysregulation or excessive senescent cells. The rapamycin rx. is from the same dr.--20% of his 480 patients are other doctors, using these things on themselves. Not only has no other cancer arrived---the detrimental effects of chemo and radiation on my nerves, heart and other things has disappeared and some functions are actually better than before I had cancer---more like when I was much younger. These are measured by blood tests, echo cardiograms, physical activity respiratory tests, etc. So---keep publishing all this info. even though you are not our only source--most of what you are publishing on this blog contains info we already read in various studies You are just reaffirming that info. It is too bad that many politicians are handling this covid19 thing incorrectly. However it is great that we have ways to work around them. (This is an incredible case history and I will email you to ask for more clarification of all you did to induce a complete response to pancreatic cancer. And yes, much of the information we published has been around for past 2 months, but we had to meticulously review it and consult with others before publishing something that suggests aggressive use of an off-label drug that has no rigorous clinical trial data to substantiate it.)
You forgot to mention „ Cytosorb „; the real deal for blocking cytokine storm, Not just IL-6. Cytosorb is an extracorporeal hemofiilter which received emergency use authorization from the FDA and has saved many lives all around the world. (We received several emails on this treatment and one of our staff is investigating it further.)
What is your opinion of the effectiveness of the use of hydroxychloroquine, azithromycin plus zinc as an early stage treatment for COVID-19 symptoms? (None of the studies to date are of rigorous design or execution, so no one yet knows if the benefits of this combination outweigh risks, nor what the real benefits are.)
It’s becoming very clear that it’s the associated inflammation, not so much the virus itself, that’s responsible for much of the mortality. I’d suggest palmitoylethanolamide as a prophylactic. Very natural, potent, and safe anti inflammatory. For the acute phase in the ICU, corticosteroids with rapamycin would be my choice. An ICU physician here in Baltimore is having great success with corticosteroids https://mycovidjourney.com/2020/04/27/good-news-from-the-front-lines/ Rapamycin has been used in the past for respiratory viruses like influenza. It is both antiviral and anti inflammatory. (This is interesting to consider but may not be potent enough when treating and acute and severe pro-inflammatory cytokine storm whereby there only may be a narrow window of time to suppress the underlying inflammatory factors.)
Sulforaphane (produced from a precursor found in broccoli sprout powder with the enzyme myrosinase from mustard seed powder- both found on Amazon) suppresses cytokine storms: https://www.researchgate.net/figure/Sulforaphane-SFN-pretreatment-reduced-inflammatory-cytokine-production-and-secretion_fig2_322664255 (Combining sulforaphane with myrosinase is interesting and likely non-toxic.)
There was an article published, which quickly disappeared from the internet, on a treatment for the last SARS virus: Inhibition of SARS-CoV 3C-like Protease Activity by Theaflavin-3,3 -digallate (TF3) Chia-Nan Chen 1, *, Coney P. C. Lin 1, *, Kuo-Kuei Huang 1 , Wei-Cheng Chen 1 , Hsin-Pang Hsieh 1 , Po-Huang Liang 2 and John T.-A. Hsu 1,3 1 Division of Biotechnology and Pharmaceutical Research, National Health Research Institutes, 2 Institute of Biological Chemistry, Academia Sinica, Taipei and 3 Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan Contrary to what is published on the LEF website, EGCg was NOT found to be an effective treatment. Here were their results: Evaluation of Tea Extracts and Pure Components from Teas for Their Inhibition of 3CL Pro Activity Since many other polyphenols related to tannic acid and TF2B are also present in various kinds of teas, we decided to examine the inhibition of activity by various tea extracts and several well known pure ingredients present in teas. Thus, water extracts from different types of teas were prepared and evaluated for their inhibitory activities against 3CL Pro . As shown in Table 1, extracts from black and Puer teas inhibited 3CL Pro activity while those from green or oolong teas did not. We further tested the possible involvement of several known ingredients present in teas, including caffeine, theophylline, catechin (C), epigallocatechin (EGC), ( )-epigallocatechin gallte (EGCg), epicatechin (EC), epicatechin gallate (ECg), TF1, TF2, TF2B, tannic acid and TF3. As shown in Table 1, the results showed that methylxanthine (caffeine and theophylline) did not influence 3CL Pro activity; catechins, including C, EC, ECg, EGC and EGCg, present in green tea (unfermented) and oolong tea (partial fermented) also did not inhibit 3CL Pro activity. Our results indicated that tannic acid, TF2B and TF3 are 3CL Pro inhibitors as revealed by the fluorogenic substrate assay (Fig. 3). TF2A was not tested because of its unavailability. (We don’t know if quercetin, EGCG and other plant extracts are able to overcome the cell’s natural built in protection against excessive infiltration of zinc. Feedback from COVID-19 patients or their family members will at least provide some anecdotal indication about this approach that has been proposed to us by well-respected physician/scientists.)
My Husband and I researched over a few years anti aging products. We discovered Ozone IV therapy along with vitamin C via I V. We now own our own Ozone equipment and do rectal insufficient every week as wells as receiving IV Bitimin C, nutrients, chelation and NAD mixed with nutrients. My health has improved beyond belief in the las 12 months , of nothing else, I recommend buying the ozone generator for rectal insufflation (We received a lot of replies suggesting ozone therapy.)
I am a healthy 79 year old male. If I were to be diagnosed (or suspected) with C19, at the first clue that my lungs were not 100%, I would spend a lot of time in the local hyperbaric oxygen machine, Once you are admitted to the hospital, it may be too late, as the lungs may not be able to pick up the oxygen anymore. I would like your feedback on my plan. (No question once your admitted to a hospital you lose control over treatments. If any mild or moderate COVID-19 patients try hyperbaric oxygen therapy, please let us know the anecdotal results if any.)
Thank you so much for this informative article. Seems to me the best advice is to maintain a strong immune system, keep inflammatory markers low through appropriate use of vitamin products, exercise, OTC products known to reduce inflammation within the body, and enough sleep suitable to you. I was curious as to why you mentioned early use of cimetidine to avoid cold virus infestation, but didn't mention zinc acetate, or other forms of zinc. (We believe that keeping inflammatory factors low provide long term benefits against degenerative aging and may reduce the magnitude of the cytokine storm in COVID-19 patients. We again will appreciate any real world feedback from those who kept their inflammatory markers low before symptomatic disease manifested and what their COVID-19 history was, e.g. mild/moderate or required hospitalization. This website is initially focused on what may work in severe and critical COVID-19 patients that is overlooked by ICU physicians. Much of what is obvious to members of the Age Reversal Network is not discussed on this website.)
Given the fact that one of the complications of severe Covid 19 is systemic hypoxemia, which may result in end-organ failure, the obvious treatment is hyperbaric oxygen known as HBOT. The latter is most known for its ability to promote wound healing but is also proven to be effective in treating multiple diseases/injuries and has been proven to be safe. I suggest that HBOT be considered to be used in the treatment of Covid 19 as adjunctive therapy to reverse the consequences of hypoxemia which could result in saving lives.
It was interesting to see that you take 800mg of cimetidine on first symptoms of an infection. I'm sure you've heard of the trial being conducted in NY using famotidine https://www.drugtopics.com/latest/famotidine-trial-underway-nyc-covid-19-treatment and I'm wondering if you see one or the other of these H2 blockers being more effective. Thank you for the excellent work and information you are providing. (The other H2 blocking drugs do NOT have cimetidine’s immune boosting properties. Famotidine is theorized to work by a different ant-viral mechanism than cimetidine. The evidence for famotidine is quite weak.)
About the Suggestions/Comments/Feedback section:
Please know that the Age Reversal Network does not have support staff to answer individual questions about COVID-19 disease treatment.
We welcome your suggestions, comments and feedback. We regularly exchange this information amongst other research groups.
The goal of these information exchanges is to rapidly identify safe and effective COVID-19 therapies.